Adjuvant Effect of Leuprolide on Stroke: A Case report
  • Carlo Sebastiano Tadeo
    Stroke Unit, Clinical Institute Città Studi, Milan
  • Barbara Incorvaia
    Stroke Unit, Clinical Institute Città Studi, Milan
  • Raffaela Russo
    Stroke Unit, Clinical Institute Città Studi, Milan
  • Luciana De Lauretis
    Gynaecology Department, Clinical Institute Città Studi, Milan


Objectives: To contribute to current knowledge on the vascular risk of oestrogens.

Materials and methods: A 44-year-old woman received a 11.25 mg Leuprolide exteneded release injection to control bleeding from a 7 cm uterine fibroid tumour; 45 days later, she had a stroke due to right frontal lobe ischaemia. Thrombolysis induced complete remission. Three years previously, while taking a birth control pill, the patient had suffered from a stroke that involved her left temporal lobe. She was heterozygous for Factor V R2 H1299R locus and homozygous for the 4G/4G mutation of the PAI-1 gene. Even though her homocysteine level was normal, the patient was homozygous for the MTHFR C677T mutation and although she had never had severe bleeding, she was also homozygous for Factor XIII V34L.

Results and conclusion: This patient's prothrombotic condition could have been enhanced by leuprolide since its stimulatory effect on oestrogen production would still have been minimally present at the time of cerebral thrombosis.



  • Van der Worp HB, Van Gujn J. Acute ischemic stroke, N Engl J Med 2007;357:572–579.
  • National Institute for Health and Care Excellence. Heavy menstrual bleeding, NICE guidelines [CG44]. London: RCOG Press, January 2007.
  • Fujiki F, Tsuboi Y, Yamada T. Stroke associated with LH-RH analogue (leuprelin) administration in a young woman, Rinsho Shinkeigaku 2007;47:234–236.
  • Coli S, Magnoni M, Melisurgo G. Myocardial infarction complicating the initial phase of an ovarian stimulation protocol, Int J Cardiol 2007;115:e56–e57.
  • Views: 904
    HTML downloads: 784
    PDF downloads: 390
    patient agreement downloads: 0

    Published: 2014-11-11
    Issue: Vol. 1 (2014) (view)

    How to cite:
    Tadeo CS, Incorvaia B, Russo R, De Lauretis L. Adjuvant Effect of Leuprolide on Stroke: A Case report. EJCRIM 2014;1 doi:10.12890/2014_000061.