Vogt-Koyanagi-Harada disease, a rare entity in Spain: the challenge of worldwide immigration and globalization

  • Alberto Benavente Fernández Internal Medicine Department, Baza Hospital, Granada, Spain
  • Sara Pérez Moyano Internal Medicine Department, Baza Hospital, Granada, Spain
  • Husein Husein-ElAhmed Dermatology Department, Baza Hospital, Granada, Spain
  • Ana María Alfaro Juárez Ophthalmology Department, Baza Hospital, Granada, Spain

Keywords

Vogt–Koyanagi–Harada disease, uveo-meningeal syndromes, aseptic meningitis

Abstract

Vogt–Koyanagi–Harada disease is rare, mediated by autoimmune melanocyte inflammation and facilitated by genetic predisposition[1-3]. The main clinical features include uveitis, meningitis, tinnitus and sensorineural deafness, and skin and hair depigmentation. It usually develops in four consecutive stages: prodromal, acute uveitic, convalescent, and chronic or recurrent[4]. In view of the first two stages, the differential diagnosis takes into account uveo-meningeal syndromes. Treatment is based on high dose corticosteroids. We present the case of a 14-year-old girl admitted to hospital with fever, progressive uveo-meningeal symptoms, and sensorineural hearing loss. After work-up, the final diagnosis of Vogt–Koyanagi–Harada disease was made.

References

  • Du L, Kijlstra A, Yang P. Vogt–Koyanagi–Harada disease: novel insights into pathophysiology, diagnosis and treatment. Prog Retin Eye Res 2016;52:84-111.

  • Lavezzo MM, Sakata VM, Morita C, Rodriguez EE, Abdallah SF, da Silva FT, et al. Vogt–Koyanagi–Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 2016;11:29.

  • Liu B, Deng T, Zhu L, Zhong J. Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt–Koyanagi–Harada disease: a systematic review and meta-analysis. Medicine 2018;97:e9914.

  • Sakata VM, da Silva FT, Hirata CE, de Carvalho JF, Yamamoto JH. Diagnosis and classification of Vogt–Koyanagi–Harada disease. Autoimmun Rev 2014;13:550–55.

  • Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S, Arellanes-García L, et al. Revised diagnostic criteria for Vogt–Koyanagi–Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001;131:647-52.
  • Published: 2018-05-08

    Issue: Vol 5 Iss 7 (view)

    Section: Articles

    How to cite:
    Benavente Fernández, A., Pérez Moyano, S., Husein-ElAhmed, H., & Alfaro Juárez, A. M. (2018). Vogt-Koyanagi-Harada disease, a rare entity in Spain: the challenge of worldwide immigration and globalization. European Journal of Case Reports in Internal Medicine, 5(7). https://doi.org/https://doi.org/10.12890/2018_000886