Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection

  • Rashid Khan Department of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAE
  • Yasmeen Ajaz Department of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAE
  • Anoop Kumar Pandey Department of Radiology, Belhoul Speciality Hospital, Dubai, UAE
  • Khalid AlSaffar Department of Neurology, Belhoul Speciality Hospital, Dubai, UAE
  • Sunil Roy Thottuvelil Narayanan Department of Cardiology, Belhoul Speciality Hospital, Dubai, UAE

Keywords

Venous thrombosis, pulmonary embolism, varicella infection, protein S deficiency, hypercoagulable state

Abstract

Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very few such reports in adults. Postulated causal factors include vasculitis, direct endothelial damage, or acquired protein S deficiency secondary to molecular mimicry. These induced autoantibodies to protein S could lead to acquired protein S deficiency and produce a hypercoagulable state causing venous sinus thrombosis. Here we report the case of a 26-year-old man who presented with cortical venous sinus thrombosis and acute pulmonary embolism following varicella infection. Both conditions responded to anticoagulation treatment.

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  • Published: 2019-09-20

    Issue: Vol 6 No 10 (view)

    Section: Articles

    How to cite:
    Khan, R., Ajaz, Y., Pandey, A., AlSaffar, K., & Narayanan, S. R. (2019). Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection. European Journal of Case Reports in Internal Medicine, 6(10). https://doi.org/https://doi.org/10.12890/2019_001171