Dose-Adjusted Beta-Lactam Antibiotic-Induced Encephalopathy in a Patient with End-Stage Renal Impairment: A Case Report
  • Chris Anthony
    Department of Cardiology, St Vincent’s Hospital, Sydney
  • Meenal Sharma
    Department of Cardiology, St Vincent’s Hospital, Sydney
  • Roberto Spina
    Department of Cardiology, St Vincent’s Hospital, Sydney
  • Peter S Macdonald
    Department of Cardiology, St Vincent’s Hospital, Sydney
  • Jacob Sevastos
    Department of Nephrology, St Vincent’s Hospital, Sydney


Introduction: Despite adherence to current guidelines regarding dose adjustment and drug-level monitoring, beta-lactam-induced encephalopathy can still occur in the setting of chronic renal impairment.

Case Report: We report what we believe is the first case of piperacillin- and tazobactam-induced encephalopathy in a patient with pre-existing cefepime-induced encephalopathy in the context of end-stage kidney disease despite adequate dose adjustment for renal impairment.



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    Published: 2015-02-11
    Issue: Vol. 2 No. 1 (2015) (view)

    How to cite:
    Anthony C, Sharma M, Spina R, Macdonald PS, Sevastos J. Dose-Adjusted Beta-Lactam Antibiotic-Induced Encephalopathy in a Patient with End-Stage Renal Impairment: A Case Report. EJCRIM 2015;2 doi:10.12890/2015_000172.

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