Psychiatric Manifestations of Sporadic Creutzfeldt-Jakob Disease Simulate Depressive Disorder with Psychotic Symptoms
  • Joana Almeida Espírito Santo
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • Rui Garcia
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • Rui Marques dos Santos
    Internal Medicine Department, University Hospital Center of Coimbra, Coimbra
  • João Lemos
    Neurology Department, University Hospital Center of Coimbra, Coimbra
  • Isabel Santana
    Neurology Department, University Hospital Center of Coimbra, Coimbra

Abstract

Creutzfeldt–Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a broad spectrum of early clinical manifestations, comprising neurological and psychiatric symptoms. The authors report the case of a patient admitted with a diagnosis of depressive disorder with psychotic symptoms, with post-mortem confirmation of CJD and discuss how CJD’s clinical heterogeneity can lead to misdiagnosis of the disease. Despite CJD’s unique pathogenesis, its kaleidoscopic presentation justifies the integrated investigation of patients with psychiatric symptoms, avoiding restrictive diagnosis.

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References

  • Tyler KL. Creutzfeldt–Jakob disease, N Engl J Med 2003;348:681–682.
  • Center for Disease Control and Prevention (CDC). Topic home and diagnostic criteria for Creutzfeldt–Jakob disease (CJD), 2010. http://www.cdc.gov/ncidod/dvrd/cjd/.
  • Wall CA, Rummans TA, Aksamit AJ, Krahn LE, Pankratz VS. Psychiatric manifestations of Creutzfeldt–Jakob disease: a 25-year analysis, J Neuropsychiatry Clin Neurosci 2005;17:489–495.
  • Asahi S, Nishikawa T, Kurata K, Morinobu S, Yamawaki S. A case of myoclonus, resembling epileptic seizure, induced by short-term sulpiride treatment, Int J Psychiatry Clin Pract 2002;6:215–216.
  • Jiménez-Jiménez FJ, García-Ruiz PJ, Molina JA. Drug-induced movement disorders, Drug Saf 1997;163:180–204.
  • Micheli FE, Pardal MM, Giannaula R, Gatto M, Parera I, Paradiso G et al. Movement disorders and depression due to flunarizine and cinnarizine, Mov Disord 1989;4:139–146.
  • Moellentine CK, Rummans TA. The varied neuropsychiatric presentations of Creutzfeldt–Jakob disease, Psychosomatics 1999;40:260–263.
  • Jardri R, DiPaola C, Lajugie C, Thomas P, Goeb JL. Depressive disorder with psychotic symptoms as psychiatric manifestation of sporadic Creutzfeldt–Jakob disease: a case report, Gen Hosp Psychiatry 2006;28:452–454.
  • Baldeiras IE, Ribeiro MH, Pacheco P, Machado A, Santana I, Cunha L et al. Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients, J Neurol 2009;256:1540–1550.
  • Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M et al. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt–Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years, Brain 2012;135:3051–3061.
  • Riemenschneider M, Wagenpfeil S, Vanderstichele H, Otto M, Wiltfang J, Kretzschmar H et al. Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt–Jakob disease from other dementias, Mol Psychiatry 2003;8:343–347.
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    Published: 2015-03-10
    Issue: Vol. 2 No. 1 (2015) (view)


    How to cite:
    1.
    Espírito Santo JA, Garcia R, Marques dos Santos R, Lemos J, Santana I. Psychiatric Manifestations of Sporadic Creutzfeldt-Jakob Disease Simulate Depressive Disorder with Psychotic Symptoms. EJCRIM 2015;2 doi:10.12890/2015_000189.

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