Radiotherapy-Associated Paraneoplastic Pemphigus and Its Complications in a Patient with Nasopharyngeal Carcinoma

  • Ali Hamza Khair Department of Internal Medicine, Shifa International Hospital, Islamabad, Pakistan
  • Aimen Asim Dar Department of Internal Medicine, Shifa International Hospital, Islamabad, Pakistan
  • Abu Baker Sheikh Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
  • Aamir Iftikhar Malik Department of Pulmonology & Critical Care, Shifa International Hospital, Islamabad, Pakistan
DOI: https://doi.org/10.12890/2020_002026

Keywords

Paraneoplastic pemphigus, radiotherapy, nasopharyngeal carcinoma

Abstract

Paraneoplastic pemphigus arising in association with non-haematological cancers is extremely rare, and there are no reported cases of a patient developing this in the setting of nasopharyngeal carcinoma and only 2 reported cases of patients developing this in response to radiotherapy. Here, we present the case of a patient who developed radiotherapy-associated paraneoplastic pemphigus in the setting of nasopharyngeal carcinoma and who then developed multiple complications.

VIEW THE ENTIRE ARTICLE

References

  • Paolino G, Didona D, Magliulo G, Iannella G, Didona B, Mercuri SR, et al. Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy. Int J Mol Sci 2017;18(12):E2532.
  • Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990;323(25):1729–1735.
  • Mimouni D, Anhalt GJ, Lazarova Z, Aho S, Kazerounian S, Kouba DJ, et al. Paraneoplastic pemphigus in children and adolescents. Br J Dermatol 2002;147(4):725–732.
  • Fried R, Lynfield Y, Vitale P, Anhalt G. Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy. J Am Acad Dermatol 1993;29(5 Pt 2):815–817.
  • Lee MS, Kossard S, Ho KK, Barnetson RS, Ravich RB. Paraneoplastic pemphigus triggered by radiotherapy. Australas J Dermatol 1995;36(4):206–210.

    • Published: 2020-11-12

    Issue: Vol 7 No 12 (view)

    Section: Articles

    How to cite:
    1.
    Khair AH, Dar AA, Sheikh AB, Malik AI. Radiotherapy-Associated Paraneoplastic Pemphigus and Its Complications in a Patient with Nasopharyngeal Carcinoma. EJCRIM 2020;7 doi:10.12890/2020_002026.