Transplant-associated Thrombotic Microangiopathy Treated with Eculizumab and Romiplostim
  • Muhammad Awidi
    Lahey Hospital and Medical Center, Burlington, Massachusetts, USA
  • Meenu Jain
    Lahey Hospital and Medical Center, Burlington, Massachusetts, USA
  • Russell Baur
    Lahey Hospital and Medical Center, Burlington, Massachusetts, USA

Keywords

Eculizumab, romiplostim, transplant thrombotic microangiopathy

Abstract

Transplant-associated thrombotic microangiopathy (TA-TMA) can occur after solid organ transplantation. It results in thrombocytopenia, haemolytic anaemia and microvascular occlusion. TA-TMA is not fully understood and treatment has not been clearly established. However, there is increasing evidence to suggest an immune-complement mediated component to its development. Eculizumab is a monoclonal antibody that inhibits the cleavage of C5 into pro-inflammatory, prothrombotic terminal complement elements and has been utilized in the treatment of atypical haemolytic uremic syndrome. We report a case of TA-TMA successfully treated with eculizumab and romiplostim. This case adds to the evidence that TA-TMA is triggered by complement dysregulation and suggests possible interventions for refractory cases.

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    Published: 2021-02-10
    Issue: 2021: Vol 8 No 2 (view)

    How to cite:
    1.
    Awidi M, Jain M, Baur R. Transplant-associated Thrombotic Microangiopathy Treated with Eculizumab and Romiplostim . EJCRIM 2021;8 doi:10.12890/2021_002294.