Marantic Endocarditis Associated with COVID-19: A Rare Case Report of a Potentially Deadly Disease
  • Kok Hoe Chan
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Ormena Joseph
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Eyad Ahmed
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Apoorva Kommidi
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Addi Suleiman
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA; Department of Cardiology, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Maria E Szabela
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA; Department of Infectious Disease, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA
  • Jihad Slim
    Department of Medical Education, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA; Department of Infectious Disease, Saint Michael’s Medical Centre, New York Medical College, Newark, New Jersey, USA

Keywords

Marantic endocarditis, non-bacterial thrombotic endocarditis, COVID-19, hypercoagulable state, COVID-19 associated coagulopathy

Abstract

Coronavirus disease 2019 (COVID-19) has overwhelmed healthcare globally with millions of cases and over 2 million deaths worldwide. The hypercoagulable state associated with COVID-19 is a well-recognized complication that carries a poor prognosis. Marantic endocarditis, or non-bacterial thrombotic endocarditis (NBTE), is caused by a sterile vegetation on the cardiac valves resulting from the deposition of fibrin and platelet aggregates. It is highly associated with the hypercoagulable and acquired inflammatory states. Herein, we report a unique and rare case of COVID-19 presenting with NBTE.

VIEW THE ENTIRE ARTICLE

References

  • Lopez JA, Ross RS, Fishbein MC, Siegel RJ. Nonbacterial thrombotic endocarditis: a review. Am Heart J 1987;113(3):773–784. doi: 10.1016/0002-8703(87)90719-8. PMID: 3548296.
  • Gross L, Friedberg CK. Nonbacterial thrombotic endocarditis: classification and general description. Arch Intern Med (Chic) 1936;58(4):620–640. doi: 10.1001/archinte.1936.00170140045004
  • Asopa S, Patel A, Khan OA, Sharma R, Ohri SK. Non-bacterial thrombotic endocarditis. Eur J Cardiothorac Surg 2007;32(5):696–701. https://doi.org/10.1016/j.ejcts.2007.07.029
  • Deppisch LM, Fayemi AO. Non-bacterial thrombotic endocarditis: clinicopathologic correlations. Am Heart J 1976;92(6):723–729. doi: 10.1016/s0002-8703(76)80008-7. PMID: 998478.
  • Bilaloglu S, Aphinyanaphongs Y, Jones S, Iturrate E, Hochman J, Berger JS . Thrombosis in hospitalized patients with COVID-19 in a New York City health system. JAMA 2020;324:799.
  • Hojnik M, George J, Ziporen L, Shoenfeld Y. Heart valve involvement (Libman-Sacks endocarditis) in the antiphospholipid syndrome. Circulation 1996;93(8):1579–1587. doi: 10.1161/01.cir.93.8.1579. PMID: 8608627.
  • Kuramoto K, Matsushita S, Yamanouchi H. Nonbacterial thrombotic endocarditis as a cause of cerebral and myocardial infarction. Jpn Circ J 1984;48(9):1000–1006. doi: 10.1253/jcj.48.1000. PMID: 6481938.
  • Macdonald RA, Robbins SL. The significance of nonbacterial thrombotic endocarditis: an autopsy and clinical study of 78 cases. Ann Intern Med1957;46(2):255–273. doi: 10.7326/0003-4819-46-2-255. PMID: 13403513.
  • Bick RL. Cancer-associated thrombosis. N Engl J Med 2003;349:109–111. doi: 10.1056/NEJMp030086. PMID: 12853582.
  • Shatila W, Rizkallah A, Saad Aldin E, Tfayli A. Nonbacterial thrombotic endocarditis as the sole manifestation of stage IV gastric cancer. J Med Case Reports 2014;8:267. doi: 10.1186/1752-1947-8-267. PMID: 25091999. PMCID: PMC4131800.
  • Balata D, Mellergård J, Ekqvist D, Baranowski J, Garcia IA, Volosyraki M, et al. Non-bacterial thrombotic endocarditis: a presentation of COVID-19. Eur J Case Rep Intern Med 2020;7(8):001811. doi: 10.12890/2020_001811.
  • Rogers LR, Cho ES, Kempin S, Posner JB. Cerebral infarction from non-bacterial thrombotic endocarditis. Clinical and pathological study including the effects of anticoagulation. Am J Med 1987;83(4):746–756. doi: 10.1016/0002-9343(87)90908-9. PMID: 3674060.
  • el-Shami K, Griffiths E, Streiff M. Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment. Oncologist 2007;12(5):518–523. doi: 10.1634/theoncologist.12-5-518. PMID: 17522239.
  • Lemos ACB, do Espírito Santo DA, Salvetti MC, Gilio RN, Agra LB, Pazin-Filho A, Miranda CH. Therapeutic versus prophylactic anticoagulation for severe COVID-19: a randomized phase II clinical trial (HESACOVID). Thromb Res 2020;196:359–366. doi: 10.1016/j.thromres.2020.09.026. PMID: 32977137. PMCID: PMC7503069.
  • Views: 843
    HTML downloads: 204
    PDF downloads: 433


    Published: 2021-03-19
    Issue: 2021: Vol 8 No 3 (view)


    How to cite:
    1.
    Chan KH, Joseph O, Ahmed E, Kommidi A, Suleiman A, Szabela ME, Slim J. Marantic Endocarditis Associated with COVID-19: A Rare Case Report of a Potentially Deadly Disease. EJCRIM 2021;8 doi:10.12890/2021_002409.