Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give?

  • Jamal Belkhouribchia Department of Internal Medicine and Endocrinology University Hospital Brussels
  • Sara Nguyen Department of Dermatology University Hospital Brussels, Belgium.

Keywords

hereditary angioedema, fresh frozen plasma, C1-inhibitor, facial swelling

Abstract

Objectives: Fresh frozen plasma (FFP) has been used in angioedema crises, however there is a risk of aggravating the symptoms as well as transmitting infections. In this report, the authors emphasize the dangers of this therapy.

Materials and methods: A 25-year-old woman with hereditary angioedema (HAE) was treated with FFP after which her symptoms escalated.

Results: Administration of purified C1-inhibitor (C1-INH) resulted in relief of her symptoms.

Conclusions: FFP is to be avoided in a HAE crisis. Newer therapies for angioedema are preferred.

Author Biographies

Jamal Belkhouribchia,
Department of Internal Medicine and Endocrinology University Hospital Brussels

Certified internist and endocrinologist with a special interest in clinical Immunology.

Member of the Department of Internal Medicine and Endocrinology of the University Hospital Brussels, Belgium.

 

Sara Nguyen,
Department of Dermatology University Hospital Brussels, Belgium. Dermatologist with a special interest in angioedema and allergy.

Member of the Department of Dermatology, University Hospital Brussels, Belgium.

References

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  • Published: 2015-09-10

    Issue: Vol 2 No 5 (2015) (view)

    Section: Articles

    How to cite:
    Belkhouribchia, J., & Nguyen, S. (2015). Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give?. European Journal of Case Reports in Internal Medicine, 2(5). https://doi.org/https://doi.org/10.12890/2015_000253