DOI: 10.12890/2015_000253

Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give?

Authors

  • Jamal Belkhouribchia Department of Internal Medicine and Endocrinology University Hospital Brussels
  • Sara Nguyen Department of Dermatology University Hospital Brussels, Belgium.

jamal.belkhouribchia@vub.ac.be

Keywords

hereditary angioedema, fresh frozen plasma, C1-inhibitor, facial swelling

Abstract

Objectives: Fresh frozen plasma (FFP) has been used in angioedema crises, however there is a risk of aggravating the symptoms as well as transmitting infections. In this report, the authors emphasize the dangers of this therapy.

Materials and methods: A 25-year-old woman with hereditary angioedema (HAE) was treated with FFP after which her symptoms escalated.

Results: Administration of purified C1-inhibitor (C1-INH) resulted in relief of her symptoms.

Conclusions: FFP is to be avoided in a HAE crisis. Newer therapies for angioedema are preferred.

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References

  1. Zuraw BL. Hereditary angioedema. NEJM 2008 Sep 4;359:1027-36.
  2. Tang R, Chen S, Zhang HY. Fresh frozen plasma for the treatment of hereditary angioedema acute attacks. Chin Med Sci J 2012;>27:92-5.
  3. Zanichelli A, Mansi M, Periti G, Cicardi M. Therapeutic management of hereditary angioedema due to C1 inhibitor deficiency. Expert Rev Clin Immunol 2013;9:477-88.
  4. Kalaria S, Craig T. Assessment of hereditary angioedema treatment risks. Allergy Asthma Proc 2013;34:519-22.
  5. Pandey S, Vyas GN. Adverse effects of plasma transfusion. Transfusion 2012;52 Suppl 1:65S-79S.

Published

2015-09-10

Issue

Vol. 2 No. 5 (2015)

How to Cite

1.
Belkhouribchia J, Nguyen S. Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give? EJCRIM [Internet]. 2015 Sep. 10 [cited 2026 Nov. 3];2(5). Available from: https://www.ejcrim.com/index.php/EJCRIM/article/view/253

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