Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give?
Keywordshereditary angioedema, fresh frozen plasma, C1-inhibitor, facial swelling
Objectives: Fresh frozen plasma (FFP) has been used in angioedema crises, however there is a risk of aggravating the symptoms as well as transmitting infections. In this report, the authors emphasize the dangers of this therapy.
Materials and methods: A 25-year-old woman with hereditary angioedema (HAE) was treated with FFP after which her symptoms escalated.
Results: Administration of purified C1-inhibitor (C1-INH) resulted in relief of her symptoms.
Conclusions: FFP is to be avoided in a HAE crisis. Newer therapies for angioedema are preferred.
Issue: Vol 2 No 5 (2015) (view)