Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
  • Carolina Amado
    Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Valter Duarte
    Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Mariana Silva Leal
    Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Margarida Cruz
    Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Gisela Ferreira
    Haematology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal

Keywords

Chronic lymphocytic leukaemia, central nervous system

Abstract

Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging.
The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards.

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    Published: 2021-11-02
    Issue: 2021: Vol 8 No 11 (view)

    How to cite:
    1.
    Amado C, Duarte V, Silva Leal M, Cruz M, Ferreira G. Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System. EJCRIM 2021;8 doi:10.12890/2021_002847.

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