Subglottic Masses Revealing Rosai-Dorfman Disease
  • Mouna Snoussi
    Department of Internal Medicine, Hedi Chaker Hospital, Sfax, Tunisia
  • Abir Derbel
    Department of Internal Medicine, Hedi Chaker Hospital, Sfax, Tunisia
  • Yosr Hentati Hentati
    Department of Medical Imaging, Hedi Chaker Hospital, Sfax, Tunisia
  • Zeineb Mnif
    Department of Medical Imaging, Hedi Chaker Hospital, Sfax, Tunisia
  • Sameh Marzouk
    Department of Internal Medicine, Hedi Chaker Hospital, Sfax, Tunisia
  • Zouheir Bahloul
    Department of Internal Medicine, Hedi Chaker Hospital, Sfax, Tunisia

Keywords

Rosai Dofmann disease, laryngeal involvement, steroids

Abstract

Rosai-Dorfman disease (RDD) is an uncommon lymphoproliferative disorder; RDD with oropharyngeal involvement is extremely rare, especially in adults. A 65-year-old woman with a complaint of progressive dyspnoea since 2016 presented with laryngeal involvement of RDD. A laryngoscopy examination revealed two solid, polypoid masses in the subglottic region, and a laryngeal biopsy concluded chronic in ammation without signs of malignancy. A second biopsy of axillary lymph nodes was performed, supporting the diagnosis of histiocytosis. The patient was treated with corticosteroids and then lost to follow-up. In 2019, she suffered from dyspnoea and a hoarse voice. Laryngoscopy examination showed a polypoid lesion causing airway obstruction at 70% and thickening of the lateral wall of the cavum. Physical examination found left axillary and submandibular adenopathy, and computed tomography revealed thickening of the supraglottic larynx narrowing the laryngeal pathway. Lymphadenectomy with immunohistochemical analysis revealed typical protein positive S-100 histiocytes and emperipolesis. The patient was treated with high doses of corticosteroids for six weeks then these were progressively decreased. The outcome was favourable; the laryngeal lesion disappeared after two weeks of treatment.

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    Published: 2023-02-03
    Issue: 2023: Vol 10 No 1 (view)


    How to cite:
    1.
    Snoussi M, Derbel A, Hentati YH, Mnif Z, Marzouk S, Bahloul Z. Subglottic Masses Revealing Rosai-Dorfman Disease. EJCRIM 2023;10 doi:10.12890/2023_003389.

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