The changing face of lung cancer: oligometastatic renal metastasis post chemo-immunotherapy combination
  • Elvis Matini
    Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland
  • Trishhani Yogaretnam
    Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland
  • Charlotte Alice Wilson
    Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland
  • Derek Power
    Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland

Keywords

Oligometastatic renal disease, Immunotherapy, Squamous NSCLC, Nephrectomy

Abstract

This report describes a rare case of oligometastatic renal disease in a 69 year-old Caucasian male with non-small cell lung cancer (NSCLC). Diagnosed with Stage IIIb, NSCLC he completed chemoradiotherapy followed by 1 year of immunotherapy. Surveillance CT scans after nearly three years showed an ill-defined lesion in the left kidney.
Biopsy results were consistent with metastasis from the known lung carcinoma. Following neo-adjuvant Pembrolizumab (200mg, q3w), the patient underwent a left radical nephrectomy, without complications. One year post-operatively, CT of the thorax, abdomen and pelvis (TAP) did not identify any recurrence.
Renal metastases were historically demonstrated predominantly by autopsy studies[1]. Any mass manifesting in the kidney in the context of previous NSCLC warrants comprehensive investigations. The combination of immunotherapy followed by definitive treatment appears to be a promising management strategy[2]. With regards to local curative options, the advantages and disadvantages of surgery and radiotherapy have been well described[3-4].

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    Published: 2023-06-07
    Issue: 2023: Vol 10 No 7 (view)


    How to cite:
    1.
    Matini E, Yogaretnam T, Wilson CA, Power D. The changing face of lung cancer: oligometastatic renal metastasis post chemo-immunotherapy combination. EJCRIM 2023;10 doi:10.12890/2023_003908.