Linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: A rare case report
  • Gi Eun Kim
    Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Soubiya Ansari
    Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Ateeque Ali
    Weill Cornell Medicine-Qatar, Doha, Qatar
  • Ehab Adams
    Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Mugahid Eltahir
    Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Department of Medical Intensive Care Unit, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar

Keywords

Drug-induced pancreatitis, acute pancreatitis, linezolid side effect

Abstract

Background: Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered.
Case Presentation: A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient's clinical status.
Conclusions: For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken.

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    Published: 2023-08-31
    Issue: 2023: Vol 10 No 10 (view)

    How to cite:
    1.
    Kim GE, Ansari S, Ali A, Adams E, Eltahir M. Linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: A rare case report. EJCRIM 2023;10 doi:10.12890/2023_004041.