Challenges in diagnosing post-splenectomy cytomegalovirus mononucleosis
  • Kim Abbegail Tan Aldecoa
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA
  • Rahul Pidikiti
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA
  • Jaisal Brar
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA
  • Geetha Krishnamoorthy
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA
  • Shamla Kalyan
    Department of Infectious Diseases, Trinity Health Oakland, Pontiac, USA
  • Cecilia Cosma
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA
  • Pritha Chitagi
    Department of Internal Medicine, Trinity Health Oakland, Pontiac, USA; Wayne State University, Detroit, USA

Keywords

cytomegalovirus, post-splenectomy, CMV mononucleosis

Abstract

Cytomegalovirus (CMV) infection is often asymptomatic. However, in certain individuals, it can cause non-specific signs and symptoms that maybe hard to recognise. The condition may therefore be overlooked or misdiagnosed, leading to prolonged illness and serious sequelae. In this case report, we present a rare instance of CMV infection in an HIV-negative patient who had a remote history of splenectomy and was experiencing prolonged fever and markedly elevated white blood cell (WBC) count.

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References

  • National Center for Immunization and Respiratory Diseases, Division of Viral Diseases. Cytomegalovirus (CMV) and Congenital CMV Infection 2020. https://www.cdc.gov/cmv/clinical/overview.html
  • Zuhair M, Smit GSA, Wallis G, Jabbar F, Smith C, Devleesschauwer B, et al. Estimation of the worldwide seroprevalence of cytomegalovirus: a systematic review and meta-analysis. Rev Med Virol 2019;29:e2034.
  • Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J 2008;5:47.
  • Liatsos GD. The immunity features and defects against primary cytomegalovirus infection post-splenectomy indicate an immunocompromised status: Medicine (Baltimore) 2019;98:e17698.
  • Ram S, Lewis LA, Rice PA. Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev 2010;23:740–80.
  • Han XY, Hellerstedt BA, Koller CA. Postsplenectomy cytomegalovirus mononucleosis is a distinct clinicopathologic syndrome. Am J Med Sci 2010;339:395–399.
  • Lewis SM, Williams A, Eisenbarth SC. Structure and function of the immune system in the spleen. Sci Immunol 2019;4:eaau6085.
  • Luu S, Spellman D, Woolley IJ. Post-splenectomy sepsis: preventative strategies, challenges, and solutions. Infect Drug Resist 2019;12:2839–2851.
  • Razonable RR, Inoue N, Pinninti SG, Boppana SB, Lazzarotto T, Gabrielli L, et al. Clinical diagnostic testing for human cytomegalovirus infections. J Infect Dis 2020;221:S74–S85.
  • Zachary KC. Ganciclovir and valganciclovir: an overview. [cited 14 November 2023]. Available from: https://www.uptodate.com/contents/ganciclovir-and-valganciclovir-an-overview
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    Published: 2024-01-08
    Issue: 2024: Vol 11 No 2 (view)


    How to cite:
    1.
    Aldecoa KAT, Pidikiti R, Brar J, Krishnamoorthy G, Kalyan S, Cosma C, Chitagi P. Challenges in diagnosing post-splenectomy cytomegalovirus mononucleosis. EJCRIM 2024;11 doi:10.12890/2024_004263.