Eosinophilic gastroenteritis following COVID-19 mRNA vaccination
  • Yuta Yoshino
    Department of Internal Medicine, Saitama Citizens Medical Center, Saitama, Japan
  • Ken Tsuboi
    Department of Internal Medicine, Saitama Citizens Medical Center, Saitama, Japan


Introduction: Large-scale clinical studies for COVID-19 vaccines have shown the infection-preventing effect and short-term adverse effects. Some rare illnesses such as eosinophilia can develop following COVID-19 vaccinations.
Case description: We report a case of 65-year-old man with unexplained abdominal pain that developed 2 weeks after COVID-19 mRNA vaccination. The patient had received a second dose of COVID-19 mRNA vaccine and revealed eosinophilia at the first visit to our hospital. Eosinophil infiltration was observed in the lamina propria of the duodenum by a step biopsy. Montelukast 10 mg was administered as the initial treatment of eosinophilic gastroenteritis (EGE), and the abdominal pain was improved.
Discussion: The strong influence of COVID-19 vaccination on the development of EGE remains unproven. Reports of eosinophilia following COVID-19 vaccination have discussed that COVID-19 mRNA vaccination triggered an eosinophilic response.
Conclusion: This case presented EGE that developed following COVID-19 mRNA vaccination, which would be a rare adverse event.



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    Published: 2024-02-12
    Issue: 2024: Vol 11 No 3 (view)

    How to cite:
    Yoshino Y, Tsuboi K. Eosinophilic gastroenteritis following COVID-19 mRNA vaccination. EJCRIM 2024;11 doi:10.12890/2024_004316.