Severe Intestinal Bleeding in a Woman with Glanzmann Thrombasthenia

Authors

• Raquel Mesquita Serviço de Medicina 2.1, Hospital dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal
• Inês Santos Serviço de Medicina 2.1, Hospital dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal
• Helena Monteiro Serviço de Medicina 2.1, Hospital dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal

raquelmsmesquita@gmail.com

Abstract

Glanzmann thrombasthenia (GT) is a rare inherited disorder associated with abnormal platelet function. Non-surgical bleeding is common and can be life-threatening. A 70-year-old woman with GT presented with a 3 week history of melena and asthenia. She had hemoglobin of 3.8 g/dL. Both upper and lower endoscopies were inconclusive. Video capsule endoscopy showed multiple angioectasias and erosions in the distal ileum. Following several days of recurring intestinal hemorrhage, only treatment with recombinant activated factor VII proved to be effective, enabling patient stabilization with no further bleeding. Control and prevention of bleeding among these patients is imperative and remains challenging.