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Zay Yar Aung, Khaled Elmagraby, Alexandra Nica
2024-05-28
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Neutropenia by non-chemotherapy drugs is an extremely rare idiosyncratic life-threatening drug reaction. Ceftriaxone and meropenem are widely used broad-spectrum antibiotics and are generally safe and well tolerated. The authors present a case of neutropenia induced by ceftriaxone and meropenem in an adult patient. The resolution of neutropenia occurred within 48 hours of ceftriaxone and meropenem being discontinued. Although antibiotic-induced neutropenia is uncommon, clinicians should be mindful of this adverse drug effect because of its potential development of severe neutropenia, septicaemia, septic shock, deep-seated infections and even death. Therefore, neutropenic sepsis treatment should be initiated without delay, particularly if the patient becomes septic and febrile. Granulocyte-colony stimulation factor (G-CSF) may be administered to facilitate the recovery process with daily monitoring of neutrophil count. Mortalities from antibiotic-induced neutropenia remain rare, with a range of 2.5–5%.
Editorial Office EJCRIM
2024-06-28
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SEARCH INDEX: 681
AS01.: 134
AS02.: 237
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AS04.: 98
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AS06.: 47
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AS11.: 128
AS12.: 69
AS13.: 131
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AS15.: 29
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AS17.: 49
AS18.: 89
AS19.: 44
AS20.: 109
AS21.: 83
CONTENTS: 138
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AS01. AMBULATORY MEDICINE
AS02. CARDIOVASCULAR DISEASES
AS03. CEREBROVASCULAR AND NEUROLOGIC DISEASES
AS04. COVID-19
AS05. DIGITAL HEALTH, TELEMEDICINE, INNOVATIVE TECHNOLOGY AND ARTIFICIAL INTELLIGENCE
AS06. EMERGENCY AND ACUTE CARE MEDICINE
AS07. ENDOCRINE AND METABOLIC DISEASES
AS08. GASTROINTESTINAL AND LIVER DISEASES
AS09. GERIATRICS AND MULTIMORBIDITY
AS10. HEALTH MANAGEMENT
AS11. INFECTIOUS DISEASES
AS12. KIDNEY AND URINARY TRACT DISEASES
AS13. ONCOLOGIC AND HEMATOLOGIC DISEASES
AS14. ORGANIZATION AND QUALITY OF HEALTH CARE
AS15. PALLIATIVE CARE
AS16. PERIOPERATIVE MEDICINE
AS17. PREVENTIVE MEDICINE
AS18. RARE DISEASES
AS19. RESPIRATORY DISEASES
AS20. RHEUMATOLOGIC AND IMMUNE-MEDIATED DISEASES
AS21. OTHER
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Lénio Couto, André Goulart, Ivone Valadão, Magda Garça, Maria Beatriz Santos, Pedro Cota, Carolina Teixeira
2021-01-08
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Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.
2.1 = | 1.762 Cit. to date |
842 Docs. to date |
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