• Register
  • Login
Skip to main content Skip to main navigation menu Skip to site footer
  • About
    • Submissions
    • Editorial Team
    • About the journal
    • Advertisers and Sponsors
    • Contact
  • Latest
  • Current
  • Archives
  • The Editor's Choice
  • Links & Events
  1. Home /
  2. Search

Search

Advanced filters
1 - 1 of 1 items
Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
Laurent Jadot, Aurelie Judong, Jean-Luc Canivet, Noel Lorenzo Villalba, Pierre Damas
2021-11-05

 

We report a case of ceftriaxone-induced encephalopathy correlated with high cerebrospinal fluid concentration. Neurotoxicity of cephalosporin is increasingly reported, especially regarding fourth-generation cephalosporins. The factors influencing the corticospinal fluid (CSF) concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in the CSF. β-lactam associated neurotoxicity is mainly related to similarities between GABA and β-lactam ring. Because of disparate CSF/plasma ratio and blood-brain barrier efflux among patients, plasmatic drug monitoring probably cannot be used as a surrogate of CSF concentration. This is, as we know, the first case of described ceftriaxone-induced encephalopathy associated with an objective excessive cerebrospinal concentration.

 

 

 

1 - 1 of 1 items
how to write a case report
have you got an interesting case? submit now
find us on facebook
improve your chances for publication
Use THIS recommended model of case report and READ the Editor-in-Chief's recommendations before submitting!

EJCRIM NEWSLETTER

INFORMATION

For Readers
For Authors
For Librarians

CURRENT ISSUE

Atom logo
RSS2 logo
RSS1 logo

Official Journal of the
European Federation of Internal Medicine
www.efim.org 

Publisher: SMC media Srl
Via Giovenale, 7 - 20136 Milan - Italy
P.IVA 07626490960
ejcrim@smc-media.eu

www.ejcrim.com - ISSN: 2284-2594 - Continuous publishing starting from 2013 - © EFIM Copyright 2018, Published by SMC Media srl, Italy - Privacy policy

More information about the publishing system, Platform and Workflow by OJS/PKP.