Primary splenic diffuse large B-cell lymphoma: a case report
  • Nuno Maia Neves
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Ana Pestana Lopes
    Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Susana Carvalho Coelho
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Anabela Raimundo
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Maria Manuela Mafra
    Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Alexandra Bayão Horta
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal

Keywords

Primary Splenic Lymphoma, Diffuse Large B-Cell Lymphoma, Non-Hodgkin Lymphoma, splenomegaly, splenic nodules

Abstract

Primary splenic lymphoma (PSL) is a rare disease and an improbable cause of splenomegaly or splenic nodules. On the contrary, splenic secondary involvement as part of an advanced lymphoproliferative disorder is more common.
The authors present the case of a 49-year-old woman with a primary splenic diffuse large B-cell lymphoma (PS-DLBCL), in which the absence of other organs’ involvement determined an ultrasound-guided biopsy of the spleen to achieve a definitive diagnosis.
With this case the authors intend to emphasise the extensive differential diagnosis of splenomegaly, splenic nodules or infiltrates, the usefulness of splenic biopsy in establishing the diagnosis and recall a rare disease, with non-specific presenting symptoms, in which the diagnostic workup is challenging.

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References

  • Abdulbaki R, Tizro P, Nava VE, Gomes da Silva M, Ascensão JL. Low-grade primary splenic CD10-positive small B-cell lymphoma/follicular lymphoma. Curr Oncol 2021;28:4821–4831.
  • Kim JK, Hahn JS, Kim GE, Yang W-I. Three cases of diffuse large B-cell lymphoma presenting as primary splenic lymphoma. Yonsei Med J 2005;46:703–709.
  • Sinit RB, Dorer RK, Flores JP, Aboulafia DM. Rare causes of isolated and progressive splenic lesions: challenges in differential diagnosis, evaluation, and treatment of primary splenic lymphomas. Clin Med Insights Blood Disord 2020;13:1179545X20926188.
  • Bairey O, Shvidel L, Perry C, Dann EJ, Ruchlemer R, Tadmor T, et al. Characteristics of primary splenic diffuse large B-cell lymphoma and role of splenectomy in improving survival. Cancer 2015;121:2909–2916.
  • Byrd KP, Vontela NR, McCullar B, Martin MG. Multi-database description of primary splenic diffuse large B cell lymphoma. Anticancer Res 2017;37:6839–6843.
  • International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 1993;329:987–994.
  • Scott DW, Mottok A, Ennishi D, Wright GW, Farinha P, Ben-Neriah S, et al. Prognostic significance of diffuse large B-cell lymphoma cell of origin determined by digital gene expression in formalin-fixed paraffin-embedded tissue biopsies. J Clin Oncol 2015;33:2848–2856.
  • Aukema SM, Siebert R, Schuuring E, van Imhoff GW, Kluin-Nelemans HC, Boerma E-J, et al. Double-hit B-cell lymphomas. Blood 2011;117:2319–2331.
  • Barrans S, Crouch S, Smith A, Turner K, Owen R, Patmore R, et al. Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. J Clin Oncol 2010;28:3360–3365.
  • Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood 2009;114:2273–2279.
  • Shustik J, Han G, Farinha P, Johnson NA, Ben Neriah S, Connors JM, et al. Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP. Haematologica 2010;95:96–101.
  • Capello D, Vitolo U, Pasqualucci L, Quattrone S, Migliaretti G, Fassone L, et al. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. Blood 2000;95:651–659.
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    Published: 2023-06-21
    Issue: 2023: Vol 10 No 7 (view)


    How to cite:
    1.
    Maia Neves N, Lopes AP, Carvalho Coelho S, Raimundo A, Mafra MM, Bayão Horta A. Primary splenic diffuse large B-cell lymphoma: a case report. EJCRIM 2023;10 doi:10.12890/2023_003932.

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