Primary splenic diffuse large B-cell lymphoma: a case report
  • Nuno Maia Neves
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Ana Pestana Lopes
    Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Susana Carvalho Coelho
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Anabela Raimundo
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Maria Manuela Mafra
    Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal
  • Alexandra Bayão Horta
    Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal

Keywords

Primary Splenic Lymphoma, Diffuse Large B-Cell Lymphoma, Non-Hodgkin Lymphoma, splenomegaly, splenic nodules

Abstract

Primary splenic lymphoma (PSL) is a rare disease and an improbable cause of splenomegaly or splenic nodules. On the contrary, splenic secondary involvement as part of an advanced lymphoproliferative disorder is more common.
The authors present the case of a 49-year-old woman with a primary splenic diffuse large B-cell lymphoma (PS-DLBCL), in which the absence of other organs’ involvement determined an ultrasound-guided biopsy of the spleen to achieve a definitive diagnosis.
With this case the authors intend to emphasise the extensive differential diagnosis of splenomegaly, splenic nodules or infiltrates, the usefulness of splenic biopsy in establishing the diagnosis and recall a rare disease, with non-specific presenting symptoms, in which the diagnostic workup is challenging.

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    Published: 2023-06-21
    Issue: 2023: Vol 10 No 7 (view)

    How to cite:
    1.
    Maia Neves N, Lopes AP, Carvalho Coelho S, Raimundo A, Mafra MM, Bayão Horta A. Primary splenic diffuse large B-cell lymphoma: a case report. EJCRIM 2023;10 doi:10.12890/2023_003932.

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