Ultrastructural evidence of eosinophil clustering and ETosis in association with damage to single tumour cells in a case of poorly cohesive NOS gastric carcinoma
  • Rosario Caruso
    Department of human pathology in adult and developmental age, ‘G. Barresi’, University of Messina, Messina, Italy
  • Valerio Caruso
    Clinical and experimental medicine department, University of Pisa, Pisa, Italy
  • Luciana Rigoli
    Department of human pathology in adult and developmental age, ‘G. Barresi’, University of Messina, Messina, Italy

Keywords

Gastric carcinoma, eosinophil ETosis, tumour cell injury, ultrastructure

Abstract

A case of poorly cohesive NOS gastric carcinoma, characterised by high-grade tumour-associated tissue eosinophilia (TATE), is studied by transmission electron microscopy. Eosinophil clustering around single tumour cells constituted a recurrent ultrastructural hallmark. Some eosinophils were in intimate contact with tumour cells and exhibited extracellular trap cell death (ETosis): a non-apoptotic cell death process, recently described in non-neoplastic, eosinophil-associated diseases. Discharge of chromatin material and specific granules, due to eosinophil ETosis, was polarised towards single tumour cells that showed various degrees of cytopathogenic changes. Our data suggest that eosinophil ETosis may exert an antitumoural activity in gastric cancer.

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    Published: 2023-08-31
    Issue: 2023: Vol 10 No 10 (view)

    How to cite:
    1.
    Caruso R, Caruso V, Rigoli L. Ultrastructural evidence of eosinophil clustering and ETosis in association with damage to single tumour cells in a case of poorly cohesive NOS gastric carcinoma. EJCRIM 2023;10 doi:10.12890/2023_004016.