Complications secondary to the use of SGLT2 inhibitors in oncological patients: a series of 5 cases
  • Luis Posado-Domínguez
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
  • Luis Figuero-Pérez
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
  • María Aranzazu Amores-Martin
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
  • Pablo Reguera-Puertas
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
  • María Martín-Galache
    Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Pediatric Department, University Hospital of Salamanca, Salamanca, Spain
  • Edel Del Barco-Morillo
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Faculty of Medicine, University of Salamanca, Salamanca, Spain
  • Emilio Fonseca-Sánchez
    Medical Oncology Department, University Hospital of Salamanca, Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Faculty of Medicine, University of Salamanca, Salamanca, Spain

Keywords

iSGLT2, cancer, metabolic acidosis, sepsis

Abstract

Sodium-glucose cotransporter-2 (iSGLT2) inhibitors, which include dapagliflozin, canagliflozin and empagliflozin, are a class of drugs initially used in the oral treatment of diabetes, heart failure and renal failure. They target the reabsorption of glucose in the kidney. Although they bring benefit to patients with these conditions and in general produce few adverse effects, in some cases, iSGLT2 can cause serious adverse effects such as metabolic acidosis, and fungal or bacterial urinary infections. Oncology patients, who in general have a weak immune system and are usually treated with chemotherapy and/or immunotherapy, are more susceptible to this type of adverse events than other patients. For this reason, it is necessary to adequately select the patients eligible to receive this type of drug and evaluate the potential benefits for them. In this series of five cases, we present two cases of metabolic acidosis, two cases of bacterial urinary sepsis, and one case of fungal urinary sepsis that occurred in patients admitted to the Medical Oncology Department of the University Hospital of Salamanca in 2023.

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    Published: 2023-12-06
    Issue: 2024: Vol 11 No 1 (view)

    How to cite:
    1.
    Posado-Domínguez L, Figuero-Pérez L, Amores-Martin MA, Reguera-Puertas P, Martín-Galache M, Del Barco-Morillo E, Fonseca-Sánchez E. Complications secondary to the use of SGLT2 inhibitors in oncological patients: a series of 5 cases. EJCRIM 2023;11 doi:10.12890/2023_004216.

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