The first report of Candida auris infection in Vietnam
  • Thong Dang-Vu
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam
  • Dung Lam-Quoc
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam
  • Ngoc Duong-Minh
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam; Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
  • Ha Vu
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam
  • Lam Nguyen-Ho
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam; Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
  • Phu Truong-Thien
    Department of Microbiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
  • Khoa Nguyen-Dang
    Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam; Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam

Keywords

Candida auris, sepsis, pneumonia, Vietnam

Abstract

Infection caused by Candida auris has rapidly become a global health threat. C. auris created a significant healthcare burden due to various complicating factors, including misidentification by commercial identification methods, potent antifungal resistance, high mortality rates and the possibility of nosocomial outbreaks through direct contact. In Vietnam, there are currently no clinical reports on C. auris infections. Here, we present four clinical cases of C. auris infections in the Department of Pulmonary Medicine of Cho Ray Hospital in southern Vietnam. Through this report, we aim to highlight the attention to the emergence of C. auris in Vietnam. Further research on C. auris infections is warranted, focusing on newly observed clinical characteristics present in all cases in this report, including hypoalbuminaemia and corticosteroid usage. Moreover, one case of resistance to amphotericin B has been identified, possibly due to prior exposure to this antifungal agent.

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References

  • Chowdhary A, Jain K, Chauhan N. Candida auris genetics and emergence. Annu Rev Microbiol 2023;77:583–602.
  • Brown GD, Denning DW, Gow NAR, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med 2012;4:165rv113.
  • Cortegiani A, Misseri G, Fasciana T, Giammanco A, Giarratano A, Chowdhary A. Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris. J Intensive Care 2018;6:69.
  • World Health Organization: WHO fungal priority pathogens list to guide research, development and public health action. [Internet]. Available at: https://www.who.int/publications/i/item/9789240060241 Geneva: World Health Organization; 2022.
  • Chowdhary A, Sharma C, Meis JF. Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally. PLoS Pathog 2017;13:e1006290.
  • Centers for Disease Control and Prevention. Antifungal susceptibility testing and interpretation 2024 [Internet] [cited 2024 Jan 29]. Available from:https://www.cdc.gov/fungal/candida-auris/c-auris-antifungal.html.
  • Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, et al. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis 2017;64:134–140.
  • Rudramurthy SM, Chakrabarti A, Paul RA, Sood P, Kaur H, Capoor MR, et al. Candida auris candidaemia in Indian ICUs: analysis of risk factors. J Antimicrob Chemother 2017;72:1794–1801.
  • Calvo B, Melo ASA, Perozo-Mena A, Hernandez M, Francisco EC, Hagen F, et al. First report of Candida auris in America: clinical and microbiological aspects of 18 episodes of candidemia. J Infect 2016;73:369–374.
  • Sakai J. 1723. Human serum albumin regulates the growth of Candida auris in vitro. Open Forum Infect Dis 2019;6(Suppl 2):S631–S632.
  • Chow NA, Muñoz JF, Gade L, Berkow EL, Li X, Welsh RM, et al. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. mBio 2020;11:e03364–19.
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    Published: 2024-02-12
    Issue: 2024: Vol 11 No 3 (view)


    How to cite:
    1.
    Dang-Vu T, Lam-Quoc D, Duong-Minh N, Vu H, Nguyen-Ho L, Truong-Thien P, Nguyen-Dang K. The first report of Candida auris infection in Vietnam. EJCRIM 2024;11 doi:10.12890/2024_004335.

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