Mad Honey Disease

  • Laurentiu Broscaru Department of Internal Medicine, St. Marienhospital, Oberhausen, Germany
  • Claudiu Dobre Department of Internal Medicine, St. Marienhospital, Oberhausen, Germany
  • Frederik Rösick Department of Internal Medicine, St. Marienhospital, Oberhausen, Germany
  • Arnela Halilovic Department of Internal Medicine, St. Marienhospital, Oberhausen, Germany
  • Dietrich Gulba Department of Internal Medicine, St. Marienhospital, Oberhausen, Germany

Abstract

A 46-years old woman presented with acute onset of nausea, vomiting and prostration in the ER. She appeared ill and was poorly responsive to verbal stimuli. The physical examination showed a systolic blood pressure of 60 mmHg and a pulse of 40 bpm. ECG was notable for slight ST-elevations in the inferior leads. Right ventricular myocardial infarction with cardiogenic shock and bradycardia was suspected. Supportive therapy with catecholamines was initiated and a emergency coronary angiography was arranged. However, lab results showed normal troponin levels and a subsequent echocardiogram showed the absence of abnormal wall motions. By thorough history taking with the spouse it turned out that the patient had consumed a Turkish honey approximately an hour before the beginning of the symptoms. The patient made a full recovery within 24 hours with only supportive therapy. In retrospect the clinical presentation was highly indicative of poisoning with Grayanotoxins from a plant, Rhododendron, which is found as contaminant in some sorts of honey in the Black Sea area. A pollen analysis confirmed the presence of Rhododendron in a honey sample.  Historically this poisoning is mentioned over the millennia as mad honey disease. The ST-elevations in the ECG were a sign of early repolarization, a non-pathological finding.  

References

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  • Published: 2017-11-20

    Issue: Vol 5 No 1 (view)

    Section: Articles

    How to cite:
    Broscaru, L., Dobre, C., Rösick, F., Halilovic, A., & Gulba, D. (2017). Mad Honey Disease. European Journal of Case Reports in Internal Medicine, 5(1). https://doi.org/https://doi.org/10.12890/2017_000742