A Case of Spontaneous Regression of Pulmonary Small Cell Carcinoma
  • Motoi Ugajin
    Department of Respiratory Medicine, Nagoya Tokushukai General Hospital, Japan
  • Hisanori Kani
    Department of Thoracic Surgery, Nagoya Tokushukai General Hospital, Japan


Spontaneous regression, pulmonary small cell carcinoma, T lymphocyte-mediated immunity, atrial natriuretic peptide


An 82-year-old man was examined using chest computed tomography after treatment for pneumonia. Imaging showed a nodular shadow in the left lower lobe with associated enlarged lymph nodes. A polypoid tumour was observed on bronchoscopic examination, and the histological findings showed pulmonary small cell carcinoma with infiltration of CD3-positive and CD8-positive lymphocytes. The patient declined any antitumoural therapy and experienced an exacerbation of heart failure treated with atrial natriuretic peptide. Eighteen months after the diagnosis, the polypoid tumour had disappeared. T lymphocyte-mediated immunity and the antitumoural effects of atrial natriuretic peptide may have influenced the observed spontaneous regression.



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    Published: 2019-07-31
    Issue: Vol 6 No 8 (view)

    How to cite:
    Ugajin M, Kani H. A Case of Spontaneous Regression of Pulmonary Small Cell Carcinoma. EJCRIM 2019;6 doi:10.12890/2019_001203.

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