Autoimmune Hepatitis–Primary Biliary Cholangitis Overlap Syndrome Triggered by COVID-19

  • Balraj Singh Department of Hematology & Oncology, Saint Joseph's University Medical Center, Paterson, NJ, USA https://orcid.org/0000-0001-7986-6031
  • Parminder Kaur Department of Cardiology, Saint Joseph's University Medical Center, Paterson, NJ, USA
  • Michael Maroules Department of Hematology & Oncology, Saint Joseph's University Medical Center, Paterson, NJ, USA
DOI: https://doi.org/10.12890/2021_002264

Keywords

Arthritis, autoimmune disease, COVID-19, SARS-CoV-2, autoimmune hepatitis, AIH, primary biliary cirrhosis, primary biliary cholangitis, overlap syndrome

Abstract

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 infection, has caused the ongoing global pandemic. Initially considered a respiratory disease, it can manifest with a wide range of complications (gastrointestinal, neurological, thromboembolic and cardiovascular) leading to multiple organ dysfunction. A range of immune complications have also been described. We report the case of a 57-year-old man with a medical history of hypertension, prediabetes and beta thalassemia minor, who was diagnosed with COVID-19 and subsequently developed fatigue and arthralgias, and whose blood work showed hyperferritinemia, elevated liver enzymes (AST/ALT/GGT), hypergammaglobulinemia, anti-smooth muscle antibody, anti-mitochondrial antibody, and anti-double-stranded DNA antibodies. The patient was diagnosed with autoimmune hepatitis–primary biliary cholangitis overlap syndrome triggered by COVID-19. To our knowledge, this is the first such case reported.

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    • Published: 2021-02-04

    Issue: 2021: Vol 8 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Singh B, Kaur P, Maroules M. Autoimmune Hepatitis–Primary Biliary Cholangitis Overlap Syndrome Triggered by COVID-19. EJCRIM 2021;8 doi:10.12890/2021_002264.

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