A Rare Case of Benign Histiocytic Neoplasm of Cutaneous Rosai–Dorfman Disease: A Case Report and Literature Review
  • Erinie Mekheal
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Sherif Roman
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Brooke Kania
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Nader Mekheal
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Sharon Awasthi
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Vinod Kumar
    St Joseph’s University Medical Center, Paterson, NJ, USA
  • Michael Maroules
    St Joseph’s University Medical Center, Paterson, NJ, USA

Keywords

Rosai–Dorfman disease, cutaneous type, lymphoproliferative disorder, emperipolesis

Abstract

Rosai–Dorfman disease (RDD) is a rare disorder characterized by the proliferation of histiocytes in lymph nodes. It can occur anywhere in the body but commonly involves the cervical area of the neck. Its clinical presentation varies and patients with skin manifestations may develop papules, nodules, plaques, or pustules. Histologically, it typically presents with emperipolesis, where intact lymphocytes are found within histiocytes. The definitive treatment of RDD is not well established given the rarity of the disease and indeed skin lesions can regress spontaneously. Therapeutic treatment options include cryotherapy, radiation, or topical agents such as steroids or retinoids. Here we describe the case of a 24-year-old Hispanic female who presented with skin manifestations which proved to be histologically positive for Rosai–Dorfman disease. The patient clinically improved following the administration of intralesional steroids.

VIEW THE ENTIRE ARTICLE

References

  • Cheng X, Cheng JL, Gao AK. A study on clinical characteristics and magnetic resonance imaging manifestations on systemic Rosai–Dorfman disease. Chin Med J (Engl) 2018;31(4):440–447.
  • Fang S, Chen AJ. Facial cutaneous Rosai–Dorfman disease: a case report and literature review. Exp Ther Med 2015;9(4):1389–1392.
  • Liu L, Huang Y, Zeng C. Infantile Rosai–Dorfman disease: an unusual case of neck swelling and a literature review. Int J Clin Exp Pathol 2020;13(12):3187–3191.
  • Mohammadi O, Zylberglait Lisigurski M, Mehra D, Pishdad R, Gulec S. Rosai–Dorfman disease and unusual local invasive presentation. Cureus 2020;12(3):e7328.
  • Thawerani H, Sanchez RL, Rosai J, Dorfman RF. The cutaneous manifestations of sinus histiocytosis with massive lymphadenopathy. Arch Dermatol 1978;114(2):191–197.

    • Views: 591
    HTML downloads: 89
    PDF downloads: 283

    Published: 2022-02-10
    Issue: 2022: Vol 9 No 2 (view)

    How to cite:
    1.
    Mekheal E, Roman S, Kania B, Mekheal N, Awasthi S, Kumar V, Maroules M. A Rare Case of Benign Histiocytic Neoplasm of Cutaneous Rosai–Dorfman Disease: A Case Report and Literature Review. EJCRIM 2022;9 doi:10.12890/2022_003139.

    Most read articles by the same author(s)