Anti-Signal Recognition Particle Myopathy in a Geriatric Patient

  • Diana Marques Ferreira Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra – Hospitais da Universidade de Coimbra
  • Patrícia Afonso Mendes Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra – Hospitais da Universidade de Coimbra
  • António Aragão Consultant of Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra – Hospitais da Universidade de Coimbra
  • Manuel Teixeira Veríssimo Associate Professor of Medicine and Head of Internal Medicine Service (Enfermaria A), Centro Hospitalar e Universitário de Coimbra – Hospitais da Universidade de Coimbra and Faculdade de Medicina da Universidade de Coimbra; President of the Sociedade Portuguesa de Medicina Interna
  • Armando Carvalho Associate Professor of Medicine and Head of Department of Internal Medicine, Centro Hospitalar e Universitário de Coimbra – Hospitais da Universidade de Coimbra and Faculdade de Medicina da Universidade de Coimbra; Sociedade Portuguesa de Medicina Interna

Keywords

Signal recognition particle, myositis, anti-SRP antibodies, idiopathic inflammatory myopathies

Abstract

Anti-signal recognition particle (SRP) myopathy is a rare idiopathic inflammatory myositis that usually affects middle-age women, and is characterized by rapidly progressive proximal and symmetrical muscle weakness, elevated creatine kinase levels, severe necrotizing immune-mediated myopathy, presence of anti-SRP autoantibodies and poor response to steroid therapy. We report a geriatric case of a previously independent patient, presenting with slow onset of proximal paraparesis, myalgia and severe gait impairment. The patient was treated with steroid and azathioprine, with laboratory and pain response but modest muscle strength improvement. The clinical presentation of this unusual patient was atypical, which hampered the correct diagnosis.

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  • Published: 2015-11-03

    Issue: Vol 2 No 7 (2015) (view)

    Section: Articles

    How to cite:
    Ferreira, D., Mendes, P., Aragão, A., Veríssimo, M., & Carvalho, A. (2015). Anti-Signal Recognition Particle Myopathy in a Geriatric Patient. European Journal of Case Reports in Internal Medicine, 2(7). https://doi.org/https://doi.org/10.12890/2015_000311