Paxlovid with Caution: Novel Case of Paxlovid-Induced Tacrolimus Toxicity in a Cardiac Transplant Patients

  • Aaisha Shah Department of Medicine, Allegheny Health Network, Pittsburgh, PA, USA
  • Adeel Nasrullah Division of Pulmonology and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA
  • Muhammad Ali Butt Department of Medicine, Allegheny Health Network, Pittsburgh, PA, USA
  • Meilin Young Division of Pulmonology and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA

Keywords

COVID-19, tacrolimus, heart transplantation, Paxlovid, phenytoin

Abstract

Tacrolimus is commonly used as a prophylactic against acute rejection in transplant patients. Tacrolimus toxicity has numerous presentations that have been well documented in the literature and can be induced by a wide variety of agents. We present a novel case of tacrolimus toxicity in a cardiac transplant patient induced by outpatient treatment for COVID-19 pneumonia with ritonavir-nirmatrelvir, which was successfully treated with phenytoin therapy.

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  • Published: 2022-09-16

    Issue: 2022: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    1.
    Shah A, Nasrullah A, Butt MA, Young M. Paxlovid with Caution: Novel Case of Paxlovid-Induced Tacrolimus Toxicity in a Cardiac Transplant Patients. EJCRIM 2022;doi:10.12890/2022_003528.