Refractory Shock Secondary to Denosumab-induced Severe Hypocalcaemia
  • Nouran Eshak
    Geriatric Division, Family Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
  • Mahmoud Abdelnabi
    Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas
  • Juthipong Benjanuwattra
    Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas
  • Amr Ismail
    Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
  • Natnicha Leelaviwat
    Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas
  • Zeyad Elharabi
    Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas
  • John Culberson
    Geriatric Division, Family Medicine Department, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

Keywords

Refractory shock, cardiogenic shock, denosumab, severe hypocalcaemia

Abstract

Denosumab is one of the most commonly used antiresorptive drugs for osteoporosis treatment and the prevention of skeletal-related events in cancer patients. The purpose of this case report is to highlight potentially life-threatening severe hypocalcaemia as a side effect of denosumab complicated by refractory shock that failed to respond to medical management including intravenous calcium, vasopressors and inotropes in an elderly man with a history of prostatic cancer.

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    Published: 2022-12-23
    Issue: 2022: Vol 9 No 12 (view)

    How to cite:
    1.
    Eshak N, Abdelnabi M, Benjanuwattra J, Ismail A, Leelaviwat N, Elharabi Z, Culberson J. Refractory Shock Secondary to Denosumab-induced Severe Hypocalcaemia. EJCRIM 2022;9 doi:10.12890/2022_003706.

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