Pain Management Options in a Patient with Livedoid Vasculopathy and Peripheral Neuropathy
  • Nageshwari Palanisamy
    Department of Internal Medicine, Michigan State University, Hurley Medical Center, Flint, MI, USA
  • Justine Chinnappan
    Department of Internal Medicine, Michigan State University, Hurley Medical Center, Flint, MI, USA
  • Ghassan Bachuwa
    Department of Internal Medicine, Michigan State University, Hurley Medical Center, Flint, MI, USA

Keywords

Livedoid vasculopathy, peripheral neuropathy, pain management

Abstract

Livedoid vasculopathy (LV) is a rare clinical condition presenting as painful lesions mostly on the lower extremities. We present a case of LV with peripheral neuropathy in a young man initially misdiagnosed and treated for cellulitis. He was started on aspirin, pentoxifylline and apixaban immediately after the diagnosis of LV. However, pain management was a real challenge for the clinicians. Hence, he was later treated with epoprostenol and amlodipine for vasodilation, steroids for any possible inflammation, and antibiotics to treat superimposed infection. Irrespective of all the above, his pain was uncontrollable, and he finally received ketamine infusions along with narcotics, achieving better pain control. Various studies support the use of intravenous immunoglobulin and anti-TNF agents for pain relief in idiopathic and secondary LV. Intermittent low-dose dabigatran has also been found to be effective in the maintenance of remission in LV. However, no large studies have yet been conducted to confirm the efficacy of these medications.

VIEW THE ENTIRE ARTICLE

References

  • Micieli R, Alavi A. Treatment for livedoid vasculopathy: a systematic review. JAMA Dermatol 2018 Feb 1;154(2):193–202. doi: 10.1001/jamadermatol.2017.4374. PMID: 29141075.
  • Soulages A, Maisonobe T, Auzou P, Petit A, Allenbach Y, Barète S, et al. Peripheral neuropathy and livedoid vasculopathy. J Neurol 2022 Jul;269(7):3779–3788. doi: 10.1007/s00415-022-11007-z. PMID: 35166926.
  • Lipsker D. Livedoid vasculopathy: how to diagnose and how to treat? J Eur Acad Dermatol Venereol 2019 Sep;33(9):1627–1628. doi: 10.1111/jdv.15830. PMID: 31468610.
  • Majmundar VD, Baxi K. Livedoid vasculopathy. 2021 Aug 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32644463.
  • Bilgic A, Ozcobanoglu S, Bozca BC, Alpsoy E. Livedoid vasculopathy: a multidisciplinary clinical approach to diagnosis and management. Int J Womens Dermatol 2021 Sep 2;7(5Part A):588–599. doi: 10.1016/j.ijwd.2021.08.013. PMID: 35024414; PMCID: PMC8721056.
  • Nuttawong S, Chularojanamontri L, Trakanwittayarak S, Pinkaew S, Chanchaemsri N, Rujitharanawong C. Direct immunofluorescence findings in livedoid vasculopathy: a 10-year study and literature review. Clin Exp Dermatol 2021 Apr;46(3):525–531. doi: 10.1111/ced.14464. PMID: 32986882.
  • Khenifer S, Thomas L, Balme B, Dalle S. Livedoid vasculopathy: thrombotic or inflammatory disease? Clin Exp Dermatol 2010 Oct;35(7):693–698. doi: 10.1111/j. 1365-2230.2009.03732.x. PMID: 19874344.
  • Vasudevan B, Neema S, Verma R. Livedoid vasculopathy: a review of pathogenesis and principles of management. Indian J Dermatol Venereol Leprol 2016 Sep–Oct;82(5):478–488. doi: 10.4103/0378-6323.183635. PMID: 27297279.
  • Bhutani S, Verma R, Verghese G. Livedoid vasculopathy managed with hyperbaric oxygen therapy. Med J Armed Forces India 2012 Oct;68(4):389–391. doi: 10.1016/j.mjafi.2012.01.002. PMID: 24532913; PMCID: PMC3862953.
  • Mofarrah R, Aberer W, Aberer E. Treatment of livedoid vasculopathy with alprostadil (PGE-1): case report and review of published literature. J Eur Acad Dermatol Venereol 2013 Feb;27(2):e252–254. doi: 10.1111/j.1468-3083.2012.04480.x. PMID: 22364635.
  • Gao Y, Jin H. Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis. J Dermatolog Treat 2022 Feb;33(1):178–183. doi: 10.1080/09546634.2020.1737634. PMID: 32116074.
  • Gao Y, Jin H. Real-world data on pain management and effectiveness of anti-tumour necrosis factor agents in refractory livedoid vasculopathy. J Eur Acad Dermatol Venereol 2022 Jan;36(1):e46–e48. doi: 10.1111/jdv.17613.
  • Gao Y, Jin H. Plasminogen activator inhibitor-1: a potential etiological role in livedoid vasculopathy. Int Wound J 2020 Dec;17(6):1902–1908. doi: 10.1111/iwj.13480. PMID: 33043622; PMCID: PMC7948802.
  • Song CH, Shin DS, Jang JW, Kim TL, Kim YG, Kim JS, et al. A case of livedoid vasculopathy successfully treated with sulodexide. Ann Dermatol 2020 Dec;32(6):508–511. doi: 10.5021/ad.2020.32.6.508. PMID: 33911794; PMCID: PMC7875231.
  • Rajan MB, Bhardwaj A, Bharti JN, Agrawal A. A novel use of intermittent low dose dabigatran for maintenance of remission in livedoid vasculopathy. Dermatol Ther 2021 Jul;34(4):e14997. doi: 10.1111/dth.14997. PMID: 34028946.
  • Jia E, Yan G, Xiao M, Geng H, Wei J, Zhang J. Refractory ulcerations associated with livedoid vasculopathy successfully treated with tofacitinib. Dermatol Ther 2020 Nov;33(6):e14470. doi: 10.1111/dth.14470. PMID: 33112475; PMCID: PMC7816240.
  • Gao Y, Jin H. Efficacy and safety of intravenous immunoglobulin for treating refractory livedoid vasculopathy: a systematic review. Ther Adv Chronic Dis 2022 May 22;13:20406223221097331. doi: 10.1177/20406223221097331. PMID: 35634570; PMCID: PMC9134453.
  • Views: 447
    HTML downloads: 183
    PDF downloads: 410


    Published: 2023-02-03
    Issue: 2023: Vol 10 No 1 (view)


    How to cite:
    1.
    Palanisamy N, Chinnappan J, Bachuwa G. Pain Management Options in a Patient with Livedoid Vasculopathy and Peripheral Neuropathy . EJCRIM 2023;10 doi:10.12890/2023_003727.

    Most read articles by the same author(s)