Gastrocnemius myositis associated with Behçet’s syndrome
  • Christian Motet
    Department of Internal Medicine, CHU Saint-Pierre, Brussels, Belgium; Department of Internal Medicine, CUB Hôpital Erasme, Brussels, Belgium
  • Isabelle Nubourgh
    Department of Internal Medicine, CHU Saint-Pierre, Brussels, Belgium
  • Frédéric Vandergheynst
    Department of Internal Medicine, CUB Hôpital Erasme, Brussels, Belgium


Behçet’s syndrome, myositis, muscle


Behçet’s syndrome is a complex vasculitis involving vessels of all sizes. The typical clinical presentation consists of recurrent oral ulcers associated with genital ulcers, and/or intra-ocular inflammation and/or cutaneous lesions. It may also involve the joints, central nervous system, cardiovascular system and gastrointestinal tract. Muscle involvement associated with Behçet’s syndrome has been rarely described. We here report two cases of muscular manifestations in the setting of Behçet’s syndrome with specific gastrocnemius muscle involvement.



  • Davatchi F, Assaa Khalil S, Calamia KT, Crook JE, Sadeghi Abdollahi B, Schirmer M, et al. The International Criteria for Behçet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2014;28:338–347.
  • >Skef W, Hamilton MJ, Arayssi T. Gastrointestinal Behçet’s disease: a review. World J Gastroenterol 2015;21:3801–3812.
  • Bicer A. Musculoskeletal findings in Behcet’s disease. Patholog Res Int 2012;2012:653806.
  • Bettiol A, Prisco D, Emmi G. Behçet: the syndrome. Rheumatology (Oxford) 2020;59(Suppl 3):iii101–iii107.
  • Kim DH, Kim SW, Yeo SM, Kang MS, Yoon YC, Sung DH. Focal vasculitic myositis as a primary manifestation of Behçet’s disease: a case series of 10 Korean patients in a locomotive medicine clinic. Rheumatology (Oxford) 2021;60:4609–4615.
  • Kim KW, Cho JH. Muscular atrophy and weakness in the lower extremities in Behçet’s disease: a case report and review of literature. World J Clin Cases 2021;9:5647–5654.
  • Jo SE, Kim YJ, Lee KH, Cho SG, Lim MJ, Kwon SR, et al. Muscular involvement of Behçet’s disease: ultrasonography, computed tomography, and magnetic resonance imaging findings. Clin Imaging 2012;36:643–646.
  • Yilmaz S, Sanal HT, Cinar M, Karslioglu Y. Muscle involvement in two Behçet cases: magnetic resonance imaging and histology findings. Jpn J Radiol 2014;32:233–237.
  • Ng F, Chiong FJK, Buchanan R, Burrell LM. A rare case of Behçet disease with generalised myositis, cardiomyositis and necrotising fasciitis. BMJ Case Rep 2016;2016:bcr2015211983.
  • Conway R, Bergin D, Carey JJ, Coughlan RJ. A case of Behcet’s syndrome presenting as focal myositis. Rheumatology (Oxford) 2012;51:975.
  • Dursun D, Akova Y, Yücel E. Myositis and scleritis associated with Behçet’s disease: an atypical presentation. Ocul Immunol Inflamm 2004;12:329–332.
  • Chebbi W, Jerbi S, Ammari W, Younes M, Sfar MH. Orbital myositis in Behçet’s disease. Joint Bone Spine 2014;81:264.
  • Velasco TO, Leggit JC. Chronic exertional compartment syndrome: a clinical update. Curr Sports Med Rep 2020;19:347–352.
  • Worthmann F, Bruns J, Türker T, Gosztonyi G. Muscular involvement in Behçet’s disease: case report and review of the literature. Neuromuscul Disord 1996;6:247–253.
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    Published: 2023-04-28
    Issue: 2023: Vol 10 No 5 (view)

    How to cite:
    Motet C, Nubourgh I, Vandergheynst F. Gastrocnemius myositis associated with Behçet’s syndrome. EJCRIM 2023;10 doi:10.12890/2023_003828.

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